abstract：BACKGROUND:A year-long pan-Canadian quality improvement collaborative (QIC) led by the Canadian Foundation for Healthcare Improvement (CFHI) supported the spread of the successful Halifax, Nova Scotia-based INSPIRED COPD Outreach Program™ to 19 teams in the 10 Canadian provinces. We describe QIC results, addressing two...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Rocker GM,Amar C,Laframboise WL,Burns J,Verma JY

更新日期：2017-07-26 00:00:00

abstract：:Cigarette smoking results in the accumulation of iron both systemically and locally, in the lung thereby causing imbalance in iron homeostasis. This disruption in iron homeostasis can be associated with oxidative stress and consequent tissue injury. Therefore, in this study, we tested the association between iron home...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ghio AJ,Hilborn ED

更新日期：2017-07-18 00:00:00

abstract：BACKGROUND:With the growing burden of COPD and associated morbidity and mortality, a need for self-management has been identified. The Self-management Programme of Activity, Coping and Education for Chronic Obstructive Pulmonary Disease (SPACE for COPD) manual was developed to support self-management in COPD patients. ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Blackmore C,Johnson-Warrington VL,Williams JE,Apps LD,Young HM,Bourne C,Singh SJ

更新日期：2017-06-07 00:00:00

abstract：BACKGROUND:COPD is a debilitating disease that affects patients' daily lives. One's daily physical activity (DPA) decreases due to multifactorial causes, and this decrease is correlated with a poor prognosis in COPD patients. Muscle wasting may at least be partly due to increased activity of the ubiquitin proteasome pa...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lee KY,Chen TT,Chiang LL,Chuang HC,Feng PH,Liu WT,Chen KY,Ho SC

更新日期：2017-05-22 00:00:00

abstract：BACKGROUND:It has been scientifically proven that pulmonary rehabilitation improves exercise tolerance and facilitates the carrying out of daily physical activities. To optimize the physical and physiological benefits, it is necessary to individualize the training intensity for each patient. The aim of this study is to...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Fabre C,Chehere B,Bart F,Mucci P,Wallaert B,Grosbois JM

更新日期：2017-05-16 00:00:00

abstract：INTRODUCTION:According to guidelines, the diagnosis of COPD should be confirmed by post-bronchodilator (post-BD) airway obstruction on spirometry; however, in clinical practice, this is not always performed. The aim of this population-based study was to compare clinical characteristics and prognosis, assessed as mortal...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Sawalha S,Hedman L,Rönmark E,Lundbäck B,Lindberg A

更新日期：2017-04-24 00:00:00

abstract：:Frailty is a state of increased risk of unfavorable outcomes when exposed to stressors, and COPD is one of the several chronic illnesses associated with the condition. However, few studies have been conducted regarding the prevalence of COPD and its related factors in Southeast Asia. The objectives of this study were ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Limpawattana P,Putraveephong S,Inthasuwan P,Boonsawat W,Theerakulpisut D,Chindaprasirt J

更新日期：2017-04-18 00:00:00

abstract：PURPOSE:The purpose of this study was to identify subtypes in patients with mild-to-moderate airflow limitation and to appreciate their clinical and socioeconomic implications. METHODS:Subjects who were aged ≥20 years and had forced expiratory volume in 1 second (FEV1) ≥60% predicted and FEV1/forced vital capacity <0....

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lee JH,Rhee CK,Kim K,Kim JA,Kim SH,Yoo KH,Kim WJ,Park YB,Park HY,Jung KS

更新日期：2017-04-12 00:00:00

abstract：BACKGROUND:Concerns have been raised that treatment of COPD with inhaled corticosteroids may increase pneumonia risk. Responding to a request from the European Medicines Agency Pharmacovigilance Risk Assessment Committee, a pooled analysis of interventional studies compared pneumonia risk with inhaled budesonide-contai...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Hollis S,Jorup C,Lythgoe D,Martensson G,Regnell P,Eckerwall G

更新日期：2017-04-05 00:00:00

abstract：INTRODUCTION:Plasminogen activator inhibitor-1 (PAI-1), a major inhibitor of fibrinolysis, is associated with thrombosis, obesity, insulin resistance, dyslipidemia, and premature aging, which all are coexisting conditions of chronic obstructive pulmonary disease (COPD). The role of PAI-1 in COPD with respect to metabol...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Waschki B,Watz H,Holz O,Magnussen H,Olejnicka B,Welte T,Rabe KF,Janciauskiene S

更新日期：2017-03-22 00:00:00

abstract：BACKGROUND:The diagnosis and assessment of COPD rely mainly on the use of spirometry, which is an effort-dependent test and requires good patient cooperation. Impulse oscillometry (IOS) is a non-volitional method that requires less effort and cooperation and presents advantages for geriatric patients. However, the clin...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Liu Z,Lin L,Liu X

更新日期：2017-03-15 00:00:00

abstract：PURPOSE:A low body mass index has been associated with high mortalities in patients with chronic obstructive pulmonary disease (COPD), and studies reveal that obesity aggravates the clinical effects of COPD. We investigated the impact of obesity on patients newly identified with COPD. PATIENTS AND METHODS:This populat...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Park JH,Lee JK,Heo EY,Kim DK,Chung HS

更新日期：2017-02-24 00:00:00

abstract：BACKGROUND:Patients with chronic obstructive pulmonary disease (COPD) often have multiple underlying comorbidities, which may lead to increased health care resource utilization (HCRU) and costs. OBJECTIVE:To describe the comorbidity profiles of COPD patients and examine the associations between the presence of comorbi...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Schwab P,Dhamane AD,Hopson SD,Moretz C,Annavarapu S,Burslem K,Renda A,Kaila S

更新日期：2017-02-23 00:00:00

abstract：OBJECTIVES:COPD is an abnormal inflammatory response characterized by decreased expression of TLR2 in patients, which is suggested to induce invasive pulmonary aspergillosis (IPA). MicroRNAs (miRNAs) have been shown to play important roles in the pathogenesis of human respiratory system disorders. Therefore, the aim of...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Xu H,Wu Y,Li L,Yuan W,Zhang D,Yan Q,Guo Z,Huang W

更新日期：2017-02-14 00:00:00

abstract：PURPOSE:COPD is characterized by an accelerated and progressive decline in forced expiratory volume in 1 second (FEV1) and lung hyperinflation. Although lung hyperinflation is the hallmark of COPD, data on the longitudinal changes in lung hyperinflation and any association with the decline in FEV1 are lacking. The aim ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Park J,Lee CH,Lee YJ,Park JS,Cho YJ,Lee JH,Lee CT,Yoon HI

更新日期：2017-02-03 00:00:00

abstract：BACKGROUND:Acute exacerbations are the leading causes of hospitalization and mortality in patients with COPD. Prognostic tools for patients with chronic COPD exist, but there are scarce data regarding acute exacerbations. We aimed to identify the prognostic factors of death and readmission after exacerbation of COPD. ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Flattet Y,Garin N,Serratrice J,Perrier A,Stirnemann J,Carballo S

更新日期：2017-01-31 00:00:00

abstract：INTRODUCTION:Early palliative care is not a common practice for patients with COPD. Important barriers are the identification of patients for palliative care and the organization of such care in this patient group. OBJECTIVE:Pulmonologists have a central role in providing good quality palliative care for patients with...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Duenk RG,Verhagen C,Dekhuijzen P,Vissers K,Engels Y,Heijdra Y

更新日期：2017-01-17 00:00:00

abstract：:[This corrects the article on p. 2749 in vol. 11, PMID: 27853362.]. ...

journal_title：International journal of chronic obstructive pulmonary disease

authors：

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is associated with an increased cardiovascular risk. However, the mechanisms for this association are yet unclear. The aim of this study was to investigate the relationship between brachial intima-media thickness (B-IMT), an independent predictor of cardiovascular...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Urban MH,Eickhoff P,Funk GC,Burghuber OC,Wolzt M,Valipour A

更新日期：2017-01-04 00:00:00

abstract：BACKGROUND:For patients with COPD, physical activity (PA) is recommended as the core component of pulmonary rehabilitation, but there is lack of a validated questionnaire for assessing the PA effectively. AIM:To evaluate the reliability and validity of the Chinese version of Physical Activity Scale for the Elderly (PA...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Tao YX,Wang L,Dong XY,Zheng H,Zheng YS,Tang XY,Zhao Y,Zhang Q

更新日期：2016-12-22 00:00:00

abstract：PURPOSE:To explore the decision-making of general practitioners (GPs) concerning treatment with antibiotics and/or oral corticosteroids and hospitalization for COPD patients with exacerbations. METHODS:Thematic analysis of seven focus groups with 53 GPs from urban and rural areas in Norway, Germany, Wales, Poland, Rus...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Laue J,Melbye H,Halvorsen PA,Andreeva EA,Godycki-Cwirko M,Wollny A,Francis NA,Spigt M,Kung K,Risør MB

更新日期：2016-12-08 00:00:00

abstract：:Etiological evidence demonstrates that there is a significant association between cigarette smoking and chronic airway inflammatory disease. Abnormal expression of placental growth factor (PlGF) has been reported in COPD, and its downstream signaling molecules have been reported to contribute to the pathogenesis of ai...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Wu D,Yuan Y,Lin Z,Lai T,Chen M,Li W,Lv Q,Yuan B,Li D,Wu B

更新日期：2016-12-02 00:00:00

abstract：:Despite the availability of guideline recommendations, diagnostic confusion between COPD and asthma appears common, and often it is very difficult to decide whether the obstruction is caused by asthma or COPD in a patient with airway obstruction. However, there are well-defined features that help in differentiating as...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Rogliani P,Ora J,Puxeddu E,Cazzola M

更新日期：2016-11-30 00:00:00

abstract：BACKGROUND:In recent decades, morbidity and mortality have been found to be significantly increased in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary tuberculosis (PTB). Platelet-lymphocyte ratio (PLR) is an indicator for inflammatory diseases. This study aims to investigate wheth...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Chen G,Wu C,Luo Z,Teng Y,Mao S

更新日期：2016-11-03 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a progressive chronic disease where treatment decisions should be based on disease severity and also should be equally distributed across age, gender, and social situation. The aim of this study was to determine to what extent patients with COPD are offered evidence-base...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Henoch I,Strang S,Löfdahl CG,Ekberg-Jansson A

更新日期：2016-10-26 00:00:00

abstract：BACKGROUND:The aim of this population-based study was to investigate the risk of developing noninfectious rhinitis (NIR) in subjects with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS:This is a longitudinal population-based study comprising 3,612 randomly selected subjects from Gothenburg, Sweden...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bergqvist J,Andersson A,Olin AC,Murgia N,Schiöler L,Bove M,Hellgren J

更新日期：2016-10-19 00:00:00

abstract：:TRPM8 plays a key role in COPD. The development of pulmonary hypertension (PH) in COPD adversely affects survival and exercise capacity. Thus, the aim of this study was to evaluate the possible association between single nucleotide polymorphisms (SNPs) in TRPM8 and COPD or PH in COPD among the Chinese Han population. ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Xiong M,Wang J,Guo M,Zhou Q,Lu W

更新日期：2016-10-14 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Alpha-1-antitrypsin deficiency (AATD) is associated with a high risk for the development of early-onset emphysema and liver disease. A large majority of subjects with severe AATD carry the ZZ genotype, which can be easily detected. Another rare pathologic variant, the Mmalton allele, causes a ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Belmonte I,Barrecheguren M,López-Martínez RM,Esquinas C,Rodríguez E,Miravitlles M,Rodríguez-Frías F

更新日期：2016-10-11 00:00:00

abstract：BACKGROUND:COPD-related deaths are increasing in Japan, with ~5.3 million people at risk. METHODS:The SHINE was a 26-week, multicenter, randomized, double-blind, parallel-group study that evaluated safety and efficacy of indacaterol (IND)/glycopyrronium (GLY) 110/50 μg once daily (od) compared with GLY 50 μg od, IND 1...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Hashimoto S,Ikeuchi H,Murata S,Kitawaki T,Ikeda K,Banerji D

更新日期：2016-10-11 00:00:00

abstract：PURPOSE:The purpose of this study was to define the prevalence of undiagnosed airflow obstruction (AO) among subjects with a history of smoking but no previous diagnosis of chronic lung disease. The finding of AO likely represents diagnosis of chronic obstructive pulmonary disease. PATIENTS:People aged ≥30 years with ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Fu SN,Yu WC,Wong CK,Lam MC

更新日期：2016-09-27 00:00:00

abstract：INTRODUCTION:Noninvasive ventilation (NIV) improves survival among patients with hypercapnic respiratory failure in hospital, but evidence for its use in domiciliary settings is limited. A patient's underlying risk of having an exacerbation may affect any potential benefit that can be gained from domiciliary NIV. This ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Dretzke J,Moore D,Dave C,Mukherjee R,Price MJ,Bayliss S,Wu X,Jordan RE,Turner AM

更新日期：2016-09-16 00:00:00

abstract：BACKGROUND:In addition to lung involvement, several other diseases and syndromes coexist in patients with chronic obstructive pulmonary disease (COPD). Our purpose was to investigate the prevalence of idiopathic arterial hypertension (IAH), ischemic heart disease, heart failure, peripheral vascular disease (PVD), diabe...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Camiciottoli G,Bigazzi F,Magni C,Bonti V,Diciotti S,Bartolucci M,Mascalchi M,Pistolesi M

更新日期：2016-09-14 00:00:00

abstract：BACKGROUND:The hallmark of COPD is chronic airway inflammation, which may be mediated by renin-angiotensin system. The renin-angiotensin system blockers such as angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) have exhibited anti-inflammatory and immunomodulatory effects in pa...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kim J,Lee JK,Heo EY,Chung HS,Kim DK

更新日期：2016-09-09 00:00:00

abstract：BACKGROUND:Homology is a mathematical concept that can be used to quantify degree of contact. Recently, image processing with the homology method has been proposed. In this study, we used the homology method and computed tomography images to quantify emphysema. METHODS:This study included 112 patients who had undergon...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Nishio M,Nakane K,Tanaka Y

更新日期：2016-09-06 00:00:00

abstract：BACKGROUND:Patients with chronic obstructive pulmonary disease (COPD) experience respiratory symptoms, which impair quality of life. This pooled analysis of two Phase III studies assessed the impact of aclidinium/formoterol on patients with COPD categorized by symptom status. METHODS:Data were pooled from two 24-week,...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Miravitlles M,Chapman KR,Chuecos F,Ribera A,Gil EG

更新日期：2016-08-29 00:00:00

abstract：BACKGROUND:Forced expiratory volume in 1 second (FEV1)/forced expiratory volume in 6 seconds (FEV6) has been proposed as an alternative to FEV1/forced vital capacity (FVC) for detecting airway obstruction. A fixed cut-off value for FEV1/FEV6 in a Korean population is lacking. We investigated a fixed cut-off for FEV1/FE...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Chung KS,Jung JY,Park MS,Kim YS,Kim SK,Chang J,Song JH

更新日期：2016-08-19 00:00:00

abstract：:Impaired physical performance is common in chronic obstructive pulmonary disease (COPD), but its assessment can be difficult in routine clinical practice. We compared the timed up and go (TUG) test and other easily applied assessments of physical performance with the 6-minute walk distance (6MWD). In a longitudinal st...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Albarrati AM,Gale NS,Enright S,Munnery MM,Cockcroft JR,Shale DJ

更新日期：2016-08-02 00:00:00

abstract：:COPD is a major cause of chronic morbidity and mortality throughout the world. Although tumor necrosis factor-α (TNF-α) has a critical role in the development of COPD, the role of different TNF receptors (TNFRs) in pulmonary emphysema has not been resolved. We aimed to clarify the role of TNFRs in the development of p...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Fujita M,Ouchi H,Ikegame S,Harada E,Matsumoto T,Uchino J,Nakanishi Y,Watanabe K

更新日期：2016-07-28 00:00:00

abstract：BACKGROUND:COPD is emerging as the third largest cause of human mortality worldwide after heart disease and stroke. Tobacco smoking, the primary risk factor for the development of COPD, induces increased expression of platelet-activating factor receptor (PAFr) in the lung epithelium. Nontypeable Haemophilus influenzae ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Shukla SD,Fairbairn RL,Gell DA,Latham RD,Sohal SS,Walters EH,O'Toole RF

更新日期：2016-07-25 00:00:00

abstract：INTRODUCTION:Randomized interventional trials generally recruit highly selected patients. In contrast, long-term, noninterventional studies can reflect standard of care of real-life populations. DACCORD (Die ambulante Versorgung mit langwirksamen Bronchodilatatoren: COPD-Register in Deutschland [Outpatient Care With Lo...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Buhl R,Criée CP,Kardos P,Vogelmeier C,Lossi N,Mailänder C,Worth H

更新日期：2016-07-20 00:00:00